Bert Vogelstein, M.D.
Our group has studied the genetics of human cancer for 30 years and has played a major role in elucidating the following principles governing the pathogenesis of human neoplasia. (i) Human tumors represent the expansion of a single transformed cell. (ii) The initiation of this process and the expansion of the transformed cell are due to mutations in specific oncogenes and tumor suppressor genes. (iii) These mutations occur in a preferred order as the tumor progresses from benign to malignant stages. (iv) Mutations in the same genes can occur either through inherited or somatic pathways. (v) Naturally occurring mutations in these genes can provide critical clues to their biochemical and physiologic functions. (vi) Heritable alterations affecting genetic stability can lead to an accelerated accumulation of somatic mutations and an associated predisposition to cancer. (vii) Knowledge of the genetic alterations responsible for cancer can be used to develop innovative approaches to improve the management of patients with neoplastic disease. Our current research is focused on point (vii): the development of novel therapeutic and diagnostic approaches for cancer patients and the development of methods to detect cancers before they have metastasized.
- Diaz, L.A. Jr., Williams, R.T., Wu., J., Kinde, I., Hecht, J.R., Berlin, J., Allen, B., Bozic, I., Reiter, J.G., Nowak, M.A., Kinzler, K.W., Oliner, K.S. and Vogelstein, B. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486: 537-540, 2012. PMCID: PMC3436069.
- Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. Jr. and Kinzler, K.W. Cancer genome landscapes. Science 339:1546-1558, 2013 PMID: 23539594 Journal – in Process.
- Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih, IeM., Kurman, R., Dao, F., Levine, D.A., Giuntoli, R., Roden, R., Eshleman, J.R., Carvalho, J.P., Marie, S.K., Papadopoulos, N., Kinzler, K.W., Vogelstein, B. and Diaz, L.A. Jr. Evaluation of DNA from the papanicolaou test detect ovarian and endometrial cancers. Sci. Transl. Med. 5: 167ra4, 2013. PMID: 23303603 Journal – in Process.