M. Daniel Lane, PhD.
Hypothalamic control of adiposity; Signals and genes that trigger adipose lineage commitment and differentiation
In this laboratory we investigate:
- the hypothalamic control of food intake, energy expenditure and obesity. The brain, notably the hypothalamus, plays a major role in energy metabolism. The hypothalamus integrates afferent signals that reflect energy status and alters the expression of neuropeptides that regulate food intake and energy expenditure and thereby, adiposity, and
- the regulatory mechanisms of gene expression and the signaling pathways that control: pluripotent stem cell commitment to the adipocyte lineage, adipocyte differentiation and adipogenesis.
- Tang, Q.-Q., Otto, T.C. and Lane, M.D. (2003) Mitotic clonal expansion: A synchronous process required for adipogenesis. Proc. Natl. Acad. Sci.,USA, 99, 44-49.
- Shimokawa, T, Kumar, M.V. and Lane, M.D.  Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. . Proc. Natl. Acad. Sci.,USA, 99, 66-71.
- Turtzo, L.C., Marx-Rattner, R., Mains, R.E and Lane, M.D. (2001)Cross-talk between sympathetic neurons and adipocytes in coculture. Proc. Natl. Acad. Sci.,USA, 98, 12385-90.
- Patel, Y.M. and Lane, M.D. (2000) Mitotic clonal expansion during preadipocyte differentiation: Calpain-mediated turnover of p27. J. Biol. Chem., 275, 17653-17660.
- Loftus, T.M., Jaworsky, D., Townsend, C.A., Ronnett, G., Lane, M.D. and Kuhajda, F.F. (2000) Reduced food intake and weight loss in mice treated with fatty acid synthase inhibitors. Science, 288, 2379-2381.
- Tang, Q.-Q. and Lane, M.D. (2000) Role of Chop-10 in the programmed activation of CCAAT/enhancer binding protein-b during adipogenesis. Proc. Natl. Acad. Sci.,USA, 97, 12446-12450.