Maimon Hubbi

Student Information
Year 2004
Undergraduate BS, Rutgers University
Mentor Dr. Gregg Semenza
Email mhubbi1@jhmi.edu


Thesis Project

Analysis of HIF1 Interactors

Hypoxia-Inducible Factor-1 (HIF1) is a transcription factor that enables cells to respond to changes in oxygen concentration. Under normoxic conditions, HIF1 has a remarkably short half-life of only a few minutes due to its degradation by prolyl hydroxylases, the von Hippel-Lindau (VHL)/Elongin-C/Elongin-B E3 ubiquitin ligase, and the proteasome. I have found several HIF1 interactors that modulate HIF1 activity in both oxygen-dependent and oxygen-independent contexts and I am focusing on the physiological relevance of these interactions.