Renee Z. Dintzis, Ph.D.
In a course offered to graduate students in the Cellular and Molecular Medicine program, Renee serve as a coordinator in their introductory course entitled "Introduction to the Human Body: Anatomy, Histology and Physiology."
Presently, I also coordinate the teaching of Histology in several Medical School and Graduate School courses. I am director of the Organ Histology section of the Organ Systems course offered to all Johns Hopkins medical students at the end of their first year.
Other projects I have been a part of include a computer database of histology entitled OVERLAYER which is accessible on Blackboard or at http://oac.med.jhmi.edu/oac/overlayer/
My scientific research background and interests have been in the field of Immunology. Although I do not now conduct laboratory research, I had previously been engaged in studying the regulatory effect of antigenic material on antibody production and the activities of B and T lymphocytes. These studies were carried out in collaboration with the laboratory of Howard Dintzis, and were aimed at determining precisely what physical and chemical properties of antigen-derivatized polymeric molecules cause them to be either immunogenic or inhibitory. We found that an antibody-producing immune response could be inhibited and prevented from recurring by treating with specific soluble antigen arrays. Such molecules were not only potent inhibitors of antibody production, but were themselves non-immunogenic at any dose. Interestingly, inhibitory polymers were not only effective in preventing an immune response from arising, but could cure a well established, ongoing antibody response. Johannes Reim, a postdoctoral fellow in Howard Dintzis' laboratory, has approached these problems using techniques of molecular genetics and cell transfer. He has convincing evidence that in the suppression of an immune response, the antibody- producing B cells of cured animals are eliminated rather than rendered anergic (i.e. alive, but incapable of responding to antigen).
- Hansel, D.E. & Dintzis, R.Z. (2006). Lippincott's Pocket Pathology. New York: Lippincott Williams & Wilkins.
- Dintzis, H.M. and Dintzis, R.Z. A Molecular Basis for Immune Regulation: The Immunon Hypothesis. In Theoretical Immunology, Part One, Volume II. A.S. Perelson, ed. Addison-Wesley Publishing Co.,Reading, Mass., pgs. 83-103 (1988).
- Dintzis, R.Z., Okajima, M., Middleton, M.H., and Dintzis, H.M. Inhibition of Antibody Formation by Receptor Cross-Linking: The Molecular Characteristics of Inhibitory Haptenated Polymers. Eur. J. Immunol. 20, 221-224, (1990).
- Dintzis, H.M. and Dintzis, R.Z. Antigens as Immunoregulators. Immunological Reviews No. 115, 243-250, (1990).
- Dintzis, Howard M. and Dintzis, Renee Z. Profound Specific Suppression by Antigen of Persistent IgM, IgG, and IgE Antibody Production. Proc. Natl. Acad. Sci.USA 89, 1113-1117, (1992)
- Dintzis, R.Z. Rational Design of Conjugate Vaccines. Ped. Research, 32, 376-385 (1992).
- Dintzis, H.M., Symer, D.E., Dintzis, R.Z., Zawadzke, L.E., Berg, J.M. A Comparison of the Immunogenicity of a Pair of Enantiomeric Proteins. Proteins 16, 306-308 (1993).
- Symer, D.E., Reim, J., Dintzis, R.Z., Voss, E.W. Jr., Dintzis, H.M. Durable Elimination of High Affinity, T Cell-Dependent Antibodies by Low Molecular Weight Antigen Arrays In Vivo. J. Immunol. 155, 5608-5616 (1995).
- Reim, J.W., Symer, D.E., Watson, D.C., Dintzis, R.Z., and Dintzis, H.M. Low Molecular Weight Antigen Arrays Delete High Affinity Memory B Cells Without Affecting Specific T-Cell Help. J. Molec. Immunol. 33, 1377-1388 (1996).