Modulation of the inflammatory response
Inflammation is the body’s response to injury. Failure to properly regulate the inflammatory response contributes to a variety of human diseases including systemic inflammatory response syndrome (SIRS), Sepsis, and multiple organ dysfunction syndrome (MODS). Our lab is focused on identifying genes involved in the modulation of the inflammatory response. Using multiple strains of mice and knock out mice, we utilize an established model to induce septic shock. We can then observe numerous phenotypic differences between the strains such as plasma cytokine levels and organ neutrophil infiltration.