Dendritic Spine Protein Interactions and Neuropathology
Schizophrenia is a severe mental illness characterized by cognitive impairments, delusions, and psychosis. Several genes have been linked to schizophrenia susceptibility, notably including DISC1, neuregulin, ErbB4, dysbindin, and NUDEL. Some of these proteins are involved in cytoskeletal functioning and may play an important role in developing or maintaining dendrites and synapses. A clearer understanding of the mechanisms through which they interact, under normal and disease conditions, could help clarify the pathology of schizophrenia, bipolar disorder, or other neurodegenerative diseases.