Zaver M. Bhujwalla, PhD.
My main research interests are understanding the role of the physiological environment and vascularization in tumor progession, invasion and metastasis.
In our laboratory, we employ both in vivo and isolated perfused cell systems. We mainly use multinuclear Magnetic Resonance (MR) Imaging (I) and Spectroscopy (S) for studying cancer cell physiology and metabolism. Reserach studies are performed on establi shed human breast cancer and prostate cancer lines. Another area of research is detecting the response of tumors to radiation and chemotherapy with MR methods. We also use multinuclear MR methods for pharmokinetic and pharmodynamic studies.
- Ackerstaff, E., Pflug, B.R., Nelson, J.B., and Bhujwalla, Z.M. Detection of Increased Choline Compounds with 1H NMR Spectroscopy following Malignant Transformation of Human Prostatic Epithelial Cells. Cancer Research, Vol. 61, pp 3599-3603, 2001.
- Pilatus, U., Aboagye, E., Artemov, D., Mori, N., Ackerstaff E., and Bhujwalla, Z M. Real-Time measurements of cellular oxygen consumption, pH and energy metabolism using Nuclear Magnetic Resonance Spectroscopy. Magnetic Resonance in Medicine, 45, pp 749-755, 2001.
- Bhujwalla, Z.M., Artemov, D., Ballesteros, P., Cerdan, C., Gillies, R.J. and Solaiyappan, M. Combined vascular and extracellular pH imaging of solid tumors. NMR in Biomedicine, 15(2):114-119, 2002. Special Issue on Angiogenesis, Editor: Kevin Brindle.
- Glunde K., Ackerstaff E., Natarajan K., Artemov D., and Bhujwalla Z.M. Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin.Magnetic Resonance in Medicine, 48(5):819-825, 2002.
- Natarajan K., Mori N., Artemov D., and Bhujwalla Z.M. Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression. Neoplasia, 4(5):409-416, 2002.
- Hafni H., Israely T., Bhujwalla Z.M., Benjamin L.E., and Neeman M. Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin. Cancer Research, 15;62(22):6731-6739,2002.
- Bhujwalla Z.M., Artemov D., Natarajan K., Solaiyappan M., Kollars P., and Kristjansen P.E. Reduction of vascular and permeable regions in solid tumors detected by macromolecular contrast magnetic resonance imaging after treatment with antiangiogenic agent TNP-470. Clinical Cancer Research, 9(1):355-362, 2003.
- Artemov D., Mori N., Okollie B., and Bhujwalla Z.M. MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles. Magnetic Resonance Medicine, 49(3):403-408, 2003.